Tottenham drift to 5-6 for top-three finish
Harry Kane is out to 6-1 from 11-4 to finish as Premier League top scorer after it was confirmed he will be out until March with an ankle injury.
The World Cup Golden Boot winner will likely miss Tottenham's two-legged Champions League tie with Dortmund as well as the second-leg of their League Cup semi-final with Chelsea.
Liverpool's Mo Salah and Pierre-Emerick Aubameyang of Arsenal are level with Kane on 14 goals at the top of the scoring charts and they have shortened to 6-4 and 5-2 respectively to scoop the individual prize.
Sergio Aguero of Manchester City is as short as 5-1 to finish as top scorer, with Chelsea's Eden Hazard 16-1.
It is a double blow for Spurs, who are light on attacking options with Heung-Min Son, who would have been most likely to deputise in Kane's absence, at the Asian Cup with South Korea.
Spurs could play Lucas Moura in a more advanced role or turn to back-up Fernando Llorente, who scored a hat-trick in the 7-0 FA Cup win at Tranmere.
Tottenham have drifted from 4-9 to 5-6 with Betfair and Paddy Power to finish in the Premier League top three and they are as big as 75-1 for the title.