United 20-1 to stay in the Champions League
Paris St-Germain have been cut to 6-1 to win the Champions League after overcoming injuries to Edinson Cavani and Neymar to beat Manchester United 2-0 at Old Trafford.
Second-half goals from Presnel Kimpembe and Kylian Mbappe saw PSG land a deserved triumph with the French champions only 1-50 to qualify for the quarter-finals.
It was a miserable night for United, who lost Anthony Martial and Jesse Lingard to injury and then saw Paul Pogba sent off for two bookable offences to rule him out of the return leg.
United, who suffered their worst European home defeat in the process, are 20-1 with bet365 to turn the tie on its head in Paris.
Roma are 4-7 to qualify for the Champions League quarter-finals after beating Porto 2-1 in the Italian capital.
All the action came late as Roma teenager Nicolo Zaniolo's double put last season's semi-finalists in a great position, only for Adrian Lopez to put Porto back in contention with a crucial away goal.
Porto are 13-8 to overturn the deficit and are now the rank outsiders of the last 16 at 250-1.