Current Holders: Inter Miami CF
| | HOME | | AWAY | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P | W | D | L | F | A | W | D | L | F | A | GD | Pts | ||
| 1 | Philadelphia U | 34 | 12 | 4 | 1 | 36 | 15 | 8 | 2 | 7 | 21 | 20 | +22 | 66 |
| 2 | Inter Miami CF | 34 | 11 | 3 | 3 | 44 | 26 | 8 | 5 | 4 | 37 | 29 | +26 | 65 |
| 3 | Cincinnati | 34 | 9 | 3 | 5 | 27 | 19 | 11 | 2 | 4 | 25 | 21 | +12 | 65 |
| 4 | Charlotte FC | 34 | 13 | 1 | 3 | 33 | 16 | 6 | 1 | 10 | 22 | 30 | +9 | 59 |
| 5 | New York City | 34 | 11 | 0 | 6 | 28 | 21 | 6 | 5 | 6 | 22 | 23 | +6 | 56 |
| 6 | Nashville MLS | 34 | 11 | 3 | 3 | 36 | 17 | 5 | 3 | 9 | 22 | 28 | +13 | 54 |
| 7 | Columbus Crew | 34 | 9 | 5 | 3 | 29 | 20 | 5 | 7 | 5 | 26 | 31 | +4 | 54 |
| 8 | Orlando City | 34 | 8 | 4 | 5 | 36 | 26 | 6 | 7 | 4 | 27 | 25 | +12 | 53 |
| 9 | Chicago | 34 | 6 | 6 | 5 | 25 | 25 | 9 | 2 | 6 | 43 | 35 | +8 | 53 |
| 10 | NY Red Bulls | 34 | 10 | 3 | 4 | 36 | 23 | 2 | 4 | 11 | 12 | 24 | +1 | 43 |
| 11 | New England | 34 | 4 | 4 | 9 | 20 | 25 | 5 | 5 | 7 | 24 | 26 | -7 | 36 |
| 12 | Atlanta U | 34 | 4 | 8 | 5 | 29 | 29 | 1 | 5 | 11 | 9 | 34 | -25 | 28 |
| 13 | Montreal Imp | 34 | 2 | 6 | 9 | 14 | 33 | 4 | 4 | 9 | 20 | 27 | -26 | 28 |
| 14 | DC United | 34 | 2 | 7 | 8 | 13 | 31 | 3 | 4 | 10 | 17 | 35 | -36 | 26 |
| 15 | Vancouver W | 34 | 10 | 4 | 3 | 42 | 20 | 8 | 5 | 4 | 24 | 18 | +28 | 63 |
| 16 | San Diego | 34 | 7 | 5 | 5 | 25 | 17 | 12 | 1 | 4 | 39 | 24 | +23 | 63 |
| 17 | Los Angeles FC | 34 | 11 | 2 | 4 | 31 | 13 | 6 | 7 | 4 | 34 | 27 | +25 | 60 |
| 18 | Minnesota U | 34 | 8 | 4 | 5 | 29 | 20 | 8 | 6 | 3 | 27 | 19 | +17 | 58 |
| 19 | Seattle | 34 | 10 | 6 | 1 | 38 | 20 | 5 | 4 | 8 | 20 | 28 | +10 | 55 |
| 20 | Austin FC | 34 | 7 | 7 | 3 | 18 | 16 | 6 | 1 | 10 | 19 | 29 | -8 | 47 |
| 21 | Dallas | 34 | 6 | 3 | 8 | 25 | 25 | 5 | 8 | 4 | 27 | 30 | -3 | 44 |
| 22 | Portland Timb. | 34 | 7 | 6 | 4 | 25 | 26 | 4 | 5 | 8 | 16 | 22 | -7 | 44 |
| 23 | San Jose | 34 | 5 | 6 | 6 | 37 | 32 | 6 | 2 | 9 | 23 | 31 | -3 | 41 |
| 24 | Real Salt Lake | 34 | 9 | 1 | 7 | 23 | 21 | 3 | 4 | 10 | 15 | 28 | -11 | 41 |
| 25 | Colorado | 34 | 8 | 4 | 5 | 25 | 21 | 3 | 4 | 10 | 19 | 35 | -12 | 41 |
| 26 | Houston | 34 | 5 | 3 | 9 | 20 | 30 | 4 | 7 | 6 | 23 | 26 | -13 | 37 |
| 27 | Toronto FC | 34 | 3 | 7 | 7 | 17 | 19 | 3 | 7 | 7 | 20 | 25 | -7 | 32 |
| 28 | St. Louis City SC | 34 | 4 | 6 | 7 | 23 | 28 | 4 | 2 | 11 | 21 | 30 | -14 | 32 |
| 29 | LA Galaxy | 34 | 7 | 2 | 8 | 27 | 28 | 0 | 7 | 10 | 19 | 38 | -20 | 30 |
| 30 | Kansas City | 34 | 4 | 5 | 8 | 25 | 32 | 3 | 2 | 12 | 21 | 38 | -24 | 28 |
