Current Holders: Inter Miami CF
| | HOME | | AWAY | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P | W | D | L | F | A | W | D | L | F | A | GD | Pts | ||
| 1 | Philadelphia U | 34 | 12 | 5 | 0 | 49 | 9 | 7 | 5 | 5 | 23 | 17 | +46 | 67 |
| 2 | Montreal Imp | 34 | 9 | 3 | 5 | 30 | 21 | 11 | 2 | 4 | 33 | 29 | +13 | 65 |
| 3 | New York City | 34 | 10 | 4 | 3 | 37 | 19 | 6 | 3 | 8 | 20 | 22 | +16 | 55 |
| 4 | NY Red Bulls | 34 | 6 | 5 | 6 | 26 | 22 | 9 | 3 | 5 | 24 | 19 | +9 | 53 |
| 5 | Cincinnati | 34 | 6 | 6 | 5 | 37 | 27 | 6 | 7 | 4 | 27 | 29 | +8 | 49 |
| 6 | Inter Miami CF | 34 | 10 | 3 | 4 | 34 | 28 | 4 | 3 | 10 | 13 | 28 | -9 | 48 |
| 7 | Orlando City | 34 | 9 | 0 | 8 | 26 | 28 | 5 | 6 | 6 | 18 | 25 | -9 | 48 |
| 8 | Columbus Crew | 34 | 7 | 6 | 4 | 22 | 15 | 3 | 10 | 4 | 24 | 26 | +5 | 46 |
| 9 | New England | 34 | 7 | 6 | 4 | 22 | 16 | 3 | 6 | 8 | 25 | 34 | -3 | 42 |
| 10 | Charlotte FC | 34 | 10 | 1 | 6 | 28 | 16 | 3 | 2 | 12 | 16 | 36 | -8 | 42 |
| 11 | Atlanta U | 34 | 8 | 5 | 4 | 31 | 24 | 2 | 5 | 10 | 17 | 30 | -6 | 40 |
| 12 | Chicago | 34 | 6 | 5 | 6 | 18 | 17 | 4 | 4 | 9 | 21 | 31 | -9 | 39 |
| 13 | Toronto FC | 34 | 7 | 3 | 7 | 30 | 29 | 2 | 4 | 11 | 19 | 37 | -17 | 34 |
| 14 | DC United | 34 | 4 | 4 | 9 | 22 | 34 | 3 | 2 | 12 | 14 | 37 | -35 | 27 |
| 15 | Los Angeles FC | 34 | 13 | 2 | 2 | 39 | 15 | 8 | 2 | 7 | 27 | 23 | +28 | 67 |
| 16 | Austin FC | 34 | 8 | 6 | 3 | 42 | 23 | 8 | 2 | 7 | 23 | 26 | +16 | 56 |
| 17 | Dallas | 34 | 10 | 4 | 3 | 28 | 15 | 4 | 7 | 6 | 20 | 22 | +11 | 53 |
| 18 | Nashville MLS | 34 | 6 | 6 | 5 | 30 | 21 | 7 | 5 | 5 | 22 | 20 | +11 | 50 |
| 19 | LA Galaxy | 34 | 8 | 4 | 5 | 35 | 25 | 6 | 4 | 7 | 23 | 26 | +7 | 50 |
| 20 | Minnesota U | 34 | 8 | 5 | 4 | 27 | 20 | 6 | 1 | 10 | 21 | 31 | -3 | 48 |
| 21 | Real Salt Lake | 34 | 9 | 5 | 3 | 27 | 15 | 3 | 6 | 8 | 16 | 30 | -2 | 47 |
| 22 | Portland Timb. | 34 | 8 | 6 | 3 | 28 | 19 | 3 | 7 | 7 | 25 | 34 | 0 | 46 |
| 23 | Colorado | 34 | 10 | 5 | 2 | 29 | 15 | 1 | 5 | 11 | 17 | 42 | -11 | 43 |
| 24 | Vancouver W | 34 | 10 | 3 | 4 | 25 | 20 | 2 | 4 | 11 | 15 | 37 | -17 | 43 |
| 25 | Seattle | 34 | 9 | 3 | 5 | 29 | 19 | 3 | 2 | 12 | 18 | 27 | +1 | 41 |
| 26 | Kansas City | 34 | 9 | 2 | 6 | 25 | 17 | 2 | 5 | 10 | 17 | 37 | -12 | 40 |
| 27 | Houston | 34 | 6 | 5 | 6 | 24 | 22 | 4 | 1 | 12 | 19 | 34 | -13 | 36 |
| 28 | San Jose | 34 | 7 | 6 | 4 | 31 | 27 | 1 | 5 | 11 | 21 | 42 | -17 | 35 |
