Current Holders: Inter Miami CF
| | HOME | | AWAY | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| P | W | D | L | F | A | W | D | L | F | A | GD | Pts | ||
| 1 | Inter Miami CF | 34 | 11 | 4 | 2 | 45 | 22 | 11 | 4 | 2 | 34 | 27 | +30 | 74 |
| 2 | Columbus Crew | 34 | 10 | 4 | 3 | 38 | 21 | 9 | 5 | 3 | 34 | 19 | +32 | 66 |
| 3 | Cincinnati | 34 | 7 | 3 | 7 | 26 | 22 | 11 | 2 | 4 | 32 | 26 | +10 | 59 |
| 4 | Orlando City | 34 | 7 | 4 | 6 | 28 | 18 | 8 | 3 | 6 | 31 | 32 | +9 | 52 |
| 5 | Charlotte FC | 34 | 9 | 5 | 3 | 25 | 15 | 5 | 4 | 8 | 21 | 22 | +9 | 51 |
| 6 | New York City | 34 | 10 | 3 | 4 | 35 | 25 | 4 | 5 | 8 | 19 | 24 | +5 | 50 |
| 7 | NY Red Bulls | 34 | 7 | 7 | 3 | 31 | 23 | 4 | 7 | 6 | 24 | 27 | +5 | 47 |
| 8 | Montreal Imp | 34 | 8 | 5 | 4 | 28 | 23 | 3 | 5 | 9 | 20 | 41 | -16 | 43 |
| 9 | Atlanta U | 34 | 6 | 4 | 7 | 30 | 27 | 4 | 6 | 7 | 16 | 22 | -3 | 40 |
| 10 | DC United | 34 | 4 | 5 | 8 | 26 | 36 | 6 | 5 | 6 | 26 | 34 | -18 | 40 |
| 11 | Philadelphia U | 34 | 4 | 5 | 8 | 27 | 23 | 5 | 5 | 7 | 35 | 32 | +7 | 37 |
| 12 | Toronto FC | 34 | 7 | 0 | 10 | 27 | 32 | 4 | 4 | 9 | 13 | 29 | -21 | 37 |
| 13 | Nashville MLS | 34 | 5 | 6 | 6 | 24 | 25 | 4 | 3 | 10 | 14 | 29 | -16 | 36 |
| 14 | New England | 34 | 5 | 4 | 8 | 19 | 30 | 4 | 0 | 13 | 18 | 44 | -37 | 31 |
| 15 | Chicago | 34 | 5 | 4 | 8 | 20 | 31 | 2 | 5 | 10 | 20 | 31 | -22 | 30 |
| 16 | Los Angeles FC | 34 | 11 | 4 | 2 | 36 | 18 | 8 | 3 | 6 | 27 | 25 | +20 | 64 |
| 17 | LA Galaxy | 34 | 13 | 3 | 1 | 43 | 25 | 6 | 4 | 7 | 26 | 25 | +19 | 64 |
| 18 | Real Salt Lake | 34 | 11 | 3 | 3 | 38 | 20 | 5 | 8 | 4 | 27 | 28 | +17 | 59 |
| 19 | Seattle | 34 | 8 | 7 | 2 | 25 | 14 | 8 | 2 | 7 | 26 | 21 | +16 | 57 |
| 20 | Houston | 34 | 7 | 7 | 3 | 22 | 15 | 8 | 2 | 7 | 25 | 24 | +8 | 54 |
| 21 | Minnesota U | 34 | 7 | 4 | 6 | 30 | 23 | 8 | 3 | 6 | 28 | 26 | +9 | 52 |
| 22 | Colorado | 34 | 10 | 3 | 4 | 33 | 22 | 5 | 2 | 10 | 28 | 38 | +1 | 50 |
| 23 | Portland Timb. | 34 | 9 | 5 | 3 | 39 | 25 | 3 | 6 | 8 | 26 | 31 | +9 | 47 |
| 24 | Vancouver W | 34 | 6 | 4 | 7 | 26 | 26 | 7 | 4 | 6 | 26 | 23 | +3 | 47 |
| 25 | Austin FC | 34 | 7 | 5 | 5 | 27 | 25 | 4 | 4 | 9 | 12 | 23 | -9 | 42 |
| 26 | Dallas | 34 | 10 | 2 | 5 | 34 | 25 | 1 | 6 | 10 | 20 | 31 | -2 | 41 |
| 27 | St. Louis City SC | 34 | 7 | 5 | 5 | 23 | 21 | 1 | 8 | 8 | 27 | 42 | -13 | 37 |
| 28 | Kansas City | 34 | 6 | 4 | 7 | 33 | 32 | 2 | 3 | 12 | 18 | 34 | -15 | 31 |
| 29 | San Jose | 34 | 4 | 1 | 12 | 18 | 32 | 2 | 2 | 13 | 23 | 46 | -37 | 21 |
